Crews were still clearing a tractor trailer pickup truck accident on 81 South Friday morning.
Marathon Fire Rescue and Ambulance were among the crews called at about 4:30 pm Thursday.
The crash closed the right lane just before the Whitney Point rest area all night.
The bigger truck loaded with crushed rock rear-ended the pickup sending both vehicles off the road.
Police at the scene described the injuries to two people in the pickup, and the tractor trailer driver as non-life threatening.